Yeast Breeding

At the end of the 20th century, yeast has played an important role in biochemistry, genetics and molecular biology as a model organism. Since the establishment of the yeast genetic transformation technology in 1978, the yeast bacteria has become one of the most useful eukaryotic microorganisms in the production of heterologous proteins and biological analysis. Subsequently, the research of yeast biology has made great progress. In 1996, the whole genome sequence of Saccharomyces cerevisiae was completed. Relevant databases have been established, such as the Saccharomyces cerevisiae Genome Database (SGD), Yeast Proteome Database (YPD), etc. The databases contain a large amount of information about 6000 genes and their protein functions, structures and relationships among yeasts.

With the in-depth development of the biological research of yeasts, the application and development of yeasts and the breeding of excellent yeasts have also been paid much attention. The research on yeasts has begun to extend to yeast breeding. Numerous yeast strains with different excellent characteristics have come out and benefit mankind.

Related applications

• Since yeast mating still exhibits cytological properties similar to somatic fusion, we will dissect the mutations that cause defects in all stages of mating, including cell fusion, and use the latest imaging methods and powerful genetic analysis methods to make yeast mating an excellent platform for studying cell fusion. An understanding of yeast cell fusion will provide insight into the fundamental mechanisms of cell signaling, cell polarization and membrane fusion.
• Research on hybrid sterility. Hybrid sterility has been an obstacle to classical genetic analysis, predictive quantitative methods, and attempts to improve strains through breeding. Currently, there are experiments to overcome infertility by creating hybrid tetraploids of yeast species, enabling continuous multi-generation reproduction. Thus, an unprecedented number of meiotic offspring with different combinations of traits is created by exploiting the genetic diversity between species.
• Yeast engineering produces low-complexity aglycosylated peptides or proteins by modifying yeast strains and develops glycoproteins with desired physicochemical properties and efficacy.
• Screening antibodies
• Research antibody drugs

Creative BioMart has accumulated many years of experience in the field of yeast research, helping our customers accelerate research in all fields using yeast as a research tool, and improve the overall success rate of the project. Please tell us your project requirements, and we will provide you with a full service from strategy design to final report. If you have any questions, please feel free to contact us.